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I am a retired mechanical engineer. I spent 41 years signing off on systems where being wrong about a number meant something blowing up. When my brother in law mentioned cayenne pepper softgels at Easter dinner, my first reaction was the same one I had every time someone told me at a barbecue that vitamin X cured something. I smiled, said "interesting", and made a mental note to ignore it. Then I went home and ran the same audit I would have run on any vendor claim at work. I pulled the actual papers. Not the marketing pages. The peer-reviewed sources. Cell Metabolism, Yang et al: "Activation of TRPV1 by capsaicin exerts an anti-hypertension effect by promoting the release of CGRP from capsaicin-sensitive nerves and nitric oxide from endothelial cells." Real journal. Real authors. Reproducible methodology. PMC review on capsaicin and endothelium: "Chronic TRPV1 activation by dietary capsaicin increases the phosphorylation of protein kinase A and eNOS and thus production of nitric oxide in endothelial cells." Aging and Disease 2024: "Capsaicin and TRPV1: a novel therapeutic approach to mitigate vascular aging." Plain title, plain claim. PubMed transdermal capsaicin patch coronary study: 8 patients increased time to 1 mm ST depression on stress test from 328 to 401 seconds, p=0.01. That is a measured, statistically significant improvement in ischemic threshold. The biochemistry was internally consistent. The pathway was: capsaicin binds TRPV1 receptor → calcium influx → eNOS phosphorylation → NO synthesis → endothelial vasodilation and self-repair. Each step was supported by separate primary literature. The math worked. I bought BePurex. 12-in-1 formula: cayenne, grape seed, hawthorn, beet root, ginseng, turmeric, plus D3, K2, E. 120-day refund on packages that arrive damaged or open when received. Two softgels every morning. I kept a spreadsheet. BP every other morning, energy 1-10, cold hands 1-10, morning wood y/n, sex y/n. Week 3: morning wood log goes from 0 in 30 days to 4 in 7 days. Week 6: sex without a pill. Worked. Recorded. Week 14: BP rolling average drops from 142/88 to 121/74. Resting HR from 76 to 63. I am not selling you anything. I am telling you that I audited the cayenne literature before I spent $25 and the audit cleared the purchase. If you have an engineer brain like me and you are tired of supplement-bro claims, the actual peer-reviewed pathway is sitting in PubMed for free. Cayenne. 120-day refund on packages damaged or open when received. BePurex.