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Dermatologist explains the number one physiological reason mature skin turns dry, wrinkly, and fragile: Trans-Epidermal Water Loss (TEWL). Imagine your skin cells are like bricks, and your natural oils (lipids) are the mortar holding them together. In your 20s and 30s, that mortar is thick and strong. But as estrogen drops after 40, your body stops producing those natural lipids. The "mortar" crumbles. Your skin barrier develops microscopic cracks and holes. Dermatologists call this a compromised lipid barrier, leading to severe Trans-Epidermal Water Loss (TEWL). Essentially, your skin can no longer hold onto hydration, water literally evaporates out of your body into the air all day long. This "leaky skin" is what causes that sudden, drastic shift to a paper-thin, deflated, and intensely wrinkled texture. -> https://goda.co/pages/crepey-skin-tewl