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RADIESSE® is officially the first and only biostimulator FDA-approved for both face and body.[1*] With the newly approved 1:2 hyperdilution protocol for décolleté treatment, you can kick-start regeneration to replenish collagen, elastin, and proteoglycans from within.[2-7] The results speak for themselves: 80% of patients felt satisfied with skin tightness[8] 83% of patients said they were likely to get RADIESSE again[8] Visible improvements that may last between 1.5 and 2 years[8,9] Discover the hyperdilution protocol and get ready to regenerate with RADIESSE. *Body indications include the hands and the décolleté. RADIESSE is diluted 1:2 with 0.9% saline to smooth away wrinkles in the décolleté of patients aged 22 years and older. RADIESSE® and RADIESSE® (+) IMPORTANT SAFETY INFORMATION RADIESSE® and RADIESSE® (+) are FDA-approved to smooth moderate to severe facial wrinkles and folds, such as nasolabial folds. RADIESSE (+) is also FDA-approved to improve moderate to severe loss of jawline contour in adults over the age of 21. RADIESSE diluted 1:2 with 0.9% sterile saline solution is indicated for subdermal implantation for the correction of décolleté wrinkles in patients 22 and older. Do not use RADIESSE and RADIESSE (+) if you have severe allergies with anaphylaxis, known hypersensitivity to any of the components, bleeding disorders, or a known hypersensitivity to lidocaine or anesthetics of the amide type. No injections of RADIESSE Injectable Implant diluted 1:2 with 0.9% sterile saline should be made in the area overlying or including breast tissue. Special caution should be exercised when treating areas in close proximity to breast implants. Delayed-onset inflammation at the site of injection following illness, infection, vaccinations, or dental procedures is a known side effect of dermal fillers. Introduction of the product into the vasculature may lead to embolization, occlusion of the vessels, ischemia, or infarction. Take extra care when injecting soft tissue fillers, for example, injecting the product slowly and applying the least amount of pressure necessary. Common side effects seen in clinical studies of RADIESSE or RADIESSE (+) include bruising, redness, swelling, pain, itching, lumps/bumps at site of injection, difficulty chewing and other local side effects. These are not all the possible side effects with RADIESSE and RADIESSE (+). Please see the Instructions for Use at www.radiesse.com for a list of these events and full Safety Information. Sources: 1. Radiesse [Instructions for Use]. Franksville, WI: Merz North America, Inc; 2026. 2. Yutskovskaya Y, et al. J Drugs Dermatol. 2014;13(9):1047-1052. 3. Yutskovskaya YA, et al. J Drugs Dermatol. 2017;16(1):68-74. 4. Yutskovskaya YA, et al. J Drugs Dermatol. 2020;19(4):405-411. 5. Nowag B, et al. CaHA microspheres: contact with fibroblasts and amount of spheres are key factors for collagen stimulation. Presented at: AMWC 2020; Monte Carlo, Monaco; April 2-4, 2020. 6. Aguilera SB, et al. Aesthet Surg J. 2023;43(10):1063-1090. 7. González N, et al. Dermatol Surg. 2019;45:547-551. 8. Data on file. Merz North America, Inc. 2025. 9. Bass LS, et al. Aesthet Surg J. 2010;30(2):235-238. #Biostimulator #RegenerativeAesthetics #MedicalAesthetics #AestheticMedicine