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Me and my little sister both have hypothyroidism. And I feel so guilty. Being lucky that I lost weight as soon as I got medicated. But her weight gain only got worse. And what makes me feel even worse is how much harder she tried than me. Just for her efforts to work against her. I got diagnosed at 37 with hypothyroidism about 1 year before my little sister. And all I did was follow my doctor's orders. I ate slightly less than usual and took my levothyroxine. I was lucky to get prescribed after my first blood test. And the weight was just coming off and my symptoms faded fast. So when my sister got diagnosed with hypo, we thought it would be the same case since we were related. That was the farthest thing from the truth. The weight was coming on by the day. I could tell because I would visit very often so we could vent to each other. I saw it in the face, neck and stomach. But I wouldn't mention it. I would lie and tell her she looked great. I still haven't got that off my chest to her. She got bloodwork done and the doctors were telling her "Your TSH is normal, let's check in 6 months from now". My sis was clearing showing symptoms of untreated hypo. I don't get why I was able to get treated right away but my sister had to wait until it got bad enough to treat. We tried talking to the doctor to look into it and he would just blame the weight gain on her over-eating. Even though I knew my sister. I knew that she had 100 times more self-control then I could ever have. I knew she was starving herself. She would cancel every invitation me and my friends would give her and I kinda knew why. My mom and dad would always try to compare her to me saying things like "alyssa looked normal after getting the disease, why aren't you?" Or like "just try harder and eat less". And when I would try to step in they would think im just covering for her. Even though it was the truth. My sister was starving herself everyday and trying harder than I ever could. But I almost cried on Easter because of her. I came to visit her house since she canceled on us again and I wanted to just sit by her and talk to her. The door was unlocked and I heard her mopping from her dresser room. I seen her crying tears I never saw her cry in my life while she was trying to zip up this pair of jeans. I grabbed her hand and tried to make her sit down but she was refusing. Eventually she just snapped at me. I remember every word so clearly. "Why the hell do you have it so easy?" "Why am I starving myself on 900 calories and gaining 3 pounds everyday." "Why does my doctor not care about me like yours." "Why am I trying so hard just to get nowhere." I kinda just started crying with her. I couldn't just watch her life disappear like this. ======== That same night once I got home I grabbed my phone and started searching. Not the usual stuff like hypothyroidism weight loss tips. I typed something like top rated endocrinologist on reddit. I figured if anyone could explain why this was happening to her and not me, it would be someone who actually specializes in this. But it had to be a doctor who actually listens. I found this doctor with like 200 something reviews. Dr. Margaret Anne. The reviews were all women saying stuff like she actually listened to me. First doctor who didn't just blame my weight on eating too much. I booked the earliest appointment I could get. $400 out of pocket. I didn't even care. I needed to understand. ======== Two weeks later I was sitting in her office. I told her everything. About me and my sister. Same diagnosis. Same medication. I lost weight like it was nothing. My sister was starving herself and gaining weight. I asked her the question that had been keeping me up. Something like why does this happen to some women and not others. She nodded like she'd heard this a thousand times. Then she asked me something no doctor had ever asked. Has anyone ever tested where your T4 is converting to T3? I didn't even know what that meant. ======== She explained it in a way that actually made sense to me. She said your body has these locks. And when they open you burn calories. T3 is the key that opens them. When your healthy and normal, your body makes these keys naturally. That's why weight loss before hypo was much easier. But when your body is under stress for too long, especially when your hypothyroid and starving, your body stops making real keys. It starts making broken ones instead. Reverse T3. ======== The broken keys look exactly like the real ones. They slide right into the lock. But they don't turn. They just jam. Get stuck. And now the real keys can't even get in. So nothing opens. Nothing burns. No matter how little you eat. And your TSH can look perfect the whole time. Because TSH just tells you keys are being sent. It doesn't tell you if they're broken. Or if your locks are jammed shut. And here's the part that made my stomach drop. ======== She said every time you starve yourself, your body thinks something is really wrong. So it panics. And makes even MORE broken keys. Jams the locks even tighter. The harder you try the more jammed you get. ======== I just sat there. Because that was exactly what was happening to my sister. 1 year of eating nothing. 1 year of trying harder than anyone I know. She wasn't failing. She was jamming herself tighter every single day. And nobody told her. ======== But then Dr. Margaret said something else. Something that changed everything. She said the broken keys are only half the problem. The real question is WHERE are those keys supposed to be made. She said T4 doesn't just magically turn into T3. It converts in your liver. That's where your body is supposed to turn T4 into the keys you can actually use. And women with thyroid issues, our livers get overwhelmed so much faster than normal. All the stress. The toxins. Everything we deal with. It builds up. And when your liver is sluggish, the conversion just can't happen the way it should. She said it's like trying to make keys in a jammed factory. Doesn't matter how much raw material you send in. If the factory can't run, no keys get made. Or worse. Broken ones do. ======== And even if your liver could work, she said conversion needs specific minerals to happen. Selenium. Zinc. Copper. Magnesium. Those are what power the process that turns T4 into T3. Without enough of them, even if your liver is fine, conversion still can't happen. And women with thyroid problems, we're always low in these. Because the thyroid issues drain them faster than normal. So there's two things blocking conversion. A sluggish liver. And not enough minerals. That's why most things don't work. They're not fixing both. ======== Dr. Margaret ran my blood test that day. My liver enzymes were normal. My body was converting fine. That's why my medication just worked. I asked if she could test my sister too. She said bring her in. ======== I drove to my sister's house that night. Told her everything I could remember. About the locks. About the broken keys. About the liver being where conversion happens. About why none of this was her fault. She didn't believe me at first. She had already been to like 4 doctors. None of them helped. But I begged her. Just one more. Please. For me. ======== A week later we were both sitting in Dr. Margaret's office. She ran my sister's blood. When the results came back she kind of just shook her head. She said something like your liver function is sluggish. Your conversion isn't happening the way it should. That's why nothing has been working. My sister just started crying. Not sad crying. Relief. Like someone finally saw what was happening to her. ======== I asked Dr. Margaret what we could do. She grabbed a notepad and started writing stuff down. The first thing she wrote was milk thistle. She said it's been used for centuries to support liver function. In Europe doctors actually prescribe it for liver problems. But the concentration matters. She said the regular milk thistle you find everywhere isn't strong enough. Women with thyroid issues have more toxic buildup than normal. So you need clinical-grade concentration to actually make a difference. Then she wrote down the minerals. Selenium. Zinc. Copper. Magnesium. She said they have to be in bioavailable forms. Not the cheap oxide versions at the store. Your body barely absorbs any of that. And she said it needs to be liquid. Because years of hypothyroidism messes up your gut. Pills don't absorb the way they should. Liquid goes under the tongue. Actually gets into your system. She said you have to fix the liver first. Then give your body the minerals it needs. In the right order. In the right forms. ======== She handed me the notepad. Then she said something I didn't expect. She said all of the women she tells this to, they go home and figure it out on their own. And cancel their follow up appointments. Even though they would be free follow-ups. They never come back to tell her what they found. They just move on with their lives. She said she wishes they would. Because she'd love to know what's actually working out there. But she can't point me to anything specific. She told me to come back if I couldn't find anything and that she could try to get something for my sister. But it wouldn't be cheap. Since everything has to be fresh and specific. About 300-500$ a month. ======== I thanked her and took the notepad home. That night I started searching. Typed the ingredients into Google. Got a bunch of random supplement sites. Nothing really matched what she wrote down. Then I went on Reddit. Typed something like hypothyroid liver conversion supplement. And I found this thread. ======== Hundreds of women talking about the same exact thing. Same symptoms my sister had. Same doctors dismissing them. Same discovery about the liver being where conversion happens. And a lot of them kept mentioning the same thing. Something called Pureveen. ======== I almost scrolled past it at first. Because I've seen so many supplements promise everything and do nothing. But these comments were different. And so much of them. One woman said she showed it to her endocrinologist and the doctor said it had the clinical-grade milk thistle concentration she recommends. Another one said it's the only thing she found with the minerals in bioavailable forms. Someone said it was liquid so she could actually absorb it. And that it addresses the liver first then the minerals. In the right order. ======== One woman said she had been eating like 900 calories and gaining weight for years. Now she eats way more and actually loses. Another one said her conversion finally started working after a few months. Another one said she told her sister about it. And now they're both finally okay. ======== That last one made me tear up. Because that's all I wanted for us. ======== I checked the ingredients on their website. It matched what Dr. Margaret wrote down. The clinical-grade milk thistle. The selenium. The zinc. The copper. The magnesium. In bioavailable forms. Liquid. I ordered it that night. Didn't even tell my sister. Just had it shipped to her house. When she called asking what it was, I told her just try it. For me. ======== She started taking it with her levo every morning. Neither of us expected anything to happen fast. ======== The first week she called me. Crying again. But different this time. She said the scale didn't go up. That's it. That's all she said. But after 2 years of gaining no matter what she did, the scale just stayed still felt like everything. ======== Week 3. She was down a few pounds. Eating more than she had in over a year. She told me she had toast for breakfast. I almost didn't believe her. She hadn't let herself have bread in like 2 years. ======== Month 2. Down 11 pounds. She came to Easter this time. Didn't cancel on us. Walked in wearing jeans. The same ones she was crying over on her floor. They zipped. ======== Month 4. Down 23 pounds. My mom pulled me aside and whispered something like "what did you do to your sister?" I just smiled. ======== She's telling me she isn't fully where she wants to be yet. And for the first time in years, she actually believes she will. ======== I tried to order another bottle for her last month. It was backordered for like 3 weeks. So if you see it available I wouldn't wait on it. ======== I'm not saying this is magic. And I'm not saying it works for everyone. But if you have hypothyroidism. And you're doing everything right and still gaining. And your doctor keeps telling you your levels are fine. Maybe you're not broken. Maybe your liver just can't convert. And nobody ever thought to check. ======== This is what I found for my sister. 👉 https://pureveen.com/products/pureveen-thyroid-balance They have a 90 day money back guarantee. If it doesn't work you get to keep it and get your money back. So there's really nothing to lose. ======== P.S. — My sister texted me this morning. She said she looked in the mirror and actually recognized herself. First time in 2 years. She said thank you for not giving up on me. I told her I never would. That's what big sisters are for.