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Over the next 20 years, the Gates Foundation will commit around $200 billion to advancing health and prosperity—about twice what we’ve invested in our first 25 years. The world is at a crossroads. The challenges ahead are the most daunting we’ve seen in our lifetime. But so are the opportunities. We’re placing our bet on human ingenuity—on the scientists, health workers, educators, and farmers whose tireless work has already delivered some of the most dramatic gains in human history. They haven’t given up. Neither will we.