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Cortisol Makes You Fat —�Here’s How to Fix It “After you turn 40, your body starts changing, and this one hormone makes it almost impossible to lose weight,” says Dr. Richard Hale, MD, Endocrinologist. He discovered a simple way to lower cortisol and finally lose stubborn weight, without strict diets or intense workouts. “I’ve seen people over 40 lose up to 50 lbs in a matter of weeks, without extreme measures.”